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- Title
Fluconazole-Resistant Candida glabrata Bloodstream Isolates, South Korea, 2008-2018.
- Authors
Eun Jeong Won; Min Ji Choi; Mi-Na Kim; Dongeun Yong; Wee Gyo Lee; Young Uh; Taek Soo Kim; Seung Ah Byeon; Seung Yeob Lee; Soo Hyun Kim; Jong Hee Shin; Won, Eun Jeong; Choi, Min Ji; Kim, Mi-Na; Yong, Dongeun; Lee, Wee Gyo; Uh, Young; Kim, Taek Soo; Byeon, Seung Ah; Lee, Seung Yeob
- Abstract
We investigated the clinical outcomes and molecular mechanisms of fluconazole-resistant (FR) Candida glabrata bloodstream infections. Among 1,158 isolates collected during multicenter studies in South Korea during 2008-2018, 5.7% were FR. For 64 patients with FR bloodstream infection isolates, the 30-day mortality rate was 60.9% and the 90-day mortality rate 78.2%; these rates were significantly higher than in patients with fluconazole-susceptible dose-dependent isolates (30-day mortality rate 36.4%, 90-day mortality rate 43.8%; p<0.05). For patients with FR isolates, appropriate antifungal therapy was the only independent protective factor associated with 30-day (hazard ratio 0.304) and 90-day (hazard ratio 0.310) mortality. Sequencing of pleiotropic drug-resistance transcription factor revealed that 1-2 additional Pdr1p amino acid substitutions (except genotype-specific Pdr1p amino acid substitutions) occurred in 98.5% of FR isolates but in only 0.9% of fluconazole-susceptible dose-dependent isolates. These results highlight the high mortality rate of patients infected with FR C. glabrata BSI isolates harboring Pdr1p mutations.
- Subjects
SOUTH Korea; CANDIDA; DEATH rate; TREATMENT effectiveness; TRANSCRIPTION factors; AMINO acids
- Publication
Emerging Infectious Diseases, 2021, Vol 27, Issue 3, p31
- ISSN
1080-6040
- Publication type
journal article
- DOI
10.3201/eid2703.203482