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- Title
Pulmonary Hypertension and Right Ventricular Dysfunction in Growth-Restricted, Extremely Low Birth Weight Neonates.
- Authors
Danhaive, Olivier; Margossian, Renée; Geva, Tal; Kourembanas, Stella
- Abstract
This case series reports an acute episode of hypoxemia and systemic hypotension in seven infants under 1 kg, taking place several hours or days after birth, after a period of stability and in the absence of significant lung disease. These patients were growth-restricted at birth and had a history of chronic fetal hypoxia and oligohydramnios. Pulmonary hypertension and right ventricular dysfunction were found by echocadiography. Right ventricular ejection fraction was significantly depressed during the acute episode, compared to baseline values measured after recovery. The timing of symptoms seemed related to ductus arteriosus closure or constriction. Oxygenation and right ventricular function improvement occurred within a few days under ventilatory and inotropic support, while milrinone was administered in five cases. In conclusion, pulmonary hypertension is a rare but significant cause of hypoxemia in preterm infants, and pulmonary vasodilator therapy should be considered in the presence of right ventricular dysfunction.Journal of Perinatology (2005) 25, 495–499. doi:10.1038/sj.jp.7211299 Published online 14 April 2005
- Subjects
PERSISTENT fetal circulation syndrome; PULMONARY hypertension; LOW birth weight; NEWBORN infants; RIGHT heart ventricle; HYPOXEMIA; PERINATOLOGY
- Publication
Journal of Perinatology, 2005, Vol 25, Issue 7, p495
- ISSN
0743-8346
- Publication type
Article
- DOI
10.1038/sj.jp.7211299