We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Antrodia cinnamomea Extract Inhibits Th17 Cell Differentiation and Ameliorates Imiquimod-Induced Psoriasiform Skin Inflammation.
- Authors
Li, Ming-Han; Wu, Hsin-Chieh; Yao, Hsin-Jan; Lin, Chi-Chen; Wen, Shu-Fang; Pan, I-Horng
- Abstract
Antrodia cinnamomea ( A. cinnamomea) is a Chinese medicinal herb that possesses a broad range of bioactivities, including anti-inflammation. Given that the proinflammatory cytokine IL-17 plays a critical role in the pathogenesis of autoimmune diseases, we investigated whether A. cinnamomea could inhibit the development of Th17 cells, the main producer of IL-17, and exhibit therapeutic effects on an animal model of psoriasis. We found that A. cinnamomea extract (AC) inhibited the differentiation of Th17 cells as well as the production of IL-17A, IL-21, and IL-22 from these cells. This effect was associated with the inhibition of STAT3 phosphorylation and RORt expression. Notably, the oral administration of AC reduced psoriasis-like inflammation in imiquimod-mediated dermal damage, repressed the expression of IL-17A, IL-22, and TNF- in skin lesions, and decreased the infiltration of CD4 T cells, CD8 T cells, and neutrophils into the dermis. Finally, serum levels of IL-17A were decreased in AC-treated mice with psoriasis-like skin inflammation. Taken together, these findings indicate that AC inhibits Th17 cell differentiation, suggesting a role for A. cinnamomea in the treatment of psoriasis and other Th17 cell-mediated inflammatory diseases.
- Subjects
INFLAMMATION prevention; ANALYSIS of variance; ANIMAL experimentation; IMMUNOMODULATORS; CHALONES; CYTOKINES; FLOW cytometry; HERBAL medicine; IMMUNOHISTOCHEMISTRY; INTERLEUKINS; MEDICINAL plants; BOTANIC medicine; CHINESE medicine; MICE; MUSHROOMS; POLYMERASE chain reaction; PROBABILITY theory; PSORIASIS; RESEARCH funding; RNA; STATISTICS; T cells; T-test (Statistics); TUMOR necrosis factors; WESTERN immunoblotting; FUNCTIONAL foods; PLANT extracts; DATA analysis; TREATMENT effectiveness; DATA analysis software
- Publication
American Journal of Chinese Medicine, 2015, Vol 43, Issue 7, p1401
- ISSN
0192-415X
- Publication type
Article
- DOI
10.1142/S0192415X15500792