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- Title
Structure and mechanism of DNA topoisomerase II.
- Authors
Berger, James M.; Gamblin, Steven J.
- Abstract
Focuses on the crystal structure of a fragment of yeast type II DNA topoisomerase revealing a heart-shaped dimeric protein with a large central hole. Function of the type II DNA topoisomerase; Formation of the two crescent-shaped monomers into a heart-shaped dimer with a large central hole; DNA binding; Adenosine triphosphatase (ATPase) domain; Mechanistic implications.
- Subjects
DNA topoisomerase II; CHEMICAL structure
- Publication
Nature, 1996, Vol 379, Issue 6562, p225
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/379225a0