We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Insulin-like growth factor-binding protein-5 (IGFBP-5) acts as a tumor suppressor by inhibiting angiogenesis.
- Authors
Seung Bae Rho; Seung Myung Dong; Sokbom Kang; Sang-Soo Seo; Chong Woo Yoo; Dong Ock Lee; Jong Soo Woo; Sang-Yoon Park
- Abstract
Insulin-like growth factor-binding protein-5 (IGFBP-5) is one of the six members of IGFBP family, important for cell growth control, induction of apoptosis and other IGF-stimulated signaling pathways. In this study, we focused on characterizing the specific function of IGFBP-5 as novel antiangiostatic factor. Overexpression of IGFBP-5 suppressed the tube formation as well as the biological functions of angiostatic activity in vivo. This result is due to the reduced expressions of phosphorylated protein kinase B and phosphorylated endothelial NO synthase, which plays important roles in the regulation of angiogenesis when stimulated by vascular endothelial growth factor. Further, IGFBP-5 expression prevented tumor growth and inhibited tumor vascularity in a xenograft model of human ovarian cancer. These results are the first evidence showing that IGFBP-5 plays a role as tumor suppressor by inhibiting angiogenesis.
- Subjects
INSULIN-like growth factor-binding proteins; TUMOR suppressor genes; NEOVASCULARIZATION inhibitors; APOPTOSIS; CELLULAR signal transduction; GENE expression; PROTEIN kinases; TUMOR suppressor proteins
- Publication
Carcinogenesis, 2008, Vol 29, Issue 11, p2106
- ISSN
0143-3334
- Publication type
Article
- DOI
10.1093/carcin/bgn206