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- Title
Formulation and Evaluation of Disulfiram Medicated Chewing Gum.
- Authors
Parouha, Poornendra; Koshta, Ashok; Jain, Nidhi; Joshi, Ankur; Malviya, Sapna; Kharia, Anil
- Abstract
Chewing gums are mobile drug delivery systems. Unlike chewable tablets, medicated gums must not be swallowed and can be removed from the application site without resorting to invasive means. Medicinal chewing gums are a solid single-dose preparation. They contain one or more active ingredients, which are released by chewing and are intended to be used for the local treatment of oral diseases or systemic intake after absorption by the oral mucosa. As for patient comfort, its discreet and easy administration without water promotes greater compliance. Since it can be taken anywhere, the chewing gum formulation is an excellent choice for acute medications. In the present study, chewing gum medicated with Disulfiram was formulated with beeswax as base, glycerol, castor oil, dextrose, calcium carbonate, polyvinylpyrrolidine, aerosol, magnesium stearate and peppermint oil. This medicated chewing gum was prepared with a direct compression method and formulated using various compositions of plasticizer castor oil and dextrose. The medicated chewing gums developed by Disulfiram were smooth, light yellow in color with a mint flavor. The presence of glycerine at an optimized concentration provided the softness for the medicated chewing gum developed. The average content of the drug in the developed medicated chewing gum was 94.14%, confirming the success of the formulation and the methodology used for its development. The drug release profile for medicated chewing gums can be significantly influenced by the frequency of chewing, therefore the drug release rate from the developed MCG was measured the maximum drug release of 94.37% was reported after 30 minutes of study on the dissolution of Batch F4.
- Subjects
CHEWING gum; ORAL mucosa; DISULFIRAM; CASTOR oil; DRUG delivery systems
- Publication
International Journal of Pharmacy & Life Sciences, 2020, Vol 11, Issue 4, p6556
- ISSN
0976-7126
- Publication type
Article