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- Title
Facile Synthesis of Multifunctional Germanium Nanoparticles as a Carrier of Quercetin to Achieve Enhanced Biological Activity.
- Authors
Guo, Yan ‐ Jie; Yang, Fen; Zhang, Lu; Pi, Jiang; Cai, Ji ‐ Ye; Yang, Pei ‐ Hui
- Abstract
A simple method for preparing quercetin surface-functionalized germanium nanoparticles (Qu-GeNPs) with enhanced antioxidant and anticancer activity is reported. Spherical germanium nanoparticles (GeNPs) were capped by quercetin (Qu) with a mean particle size of approximately 33 nm and were characterized by TEM, AFM, UV-visible absorption spectroscopy, FTIR, and XRD measurements. The in vitro drug release of Qu from the Qu-GeNPs indicated that Qu could principally be distributed around tumor tissues rather than in the normal section and Qu-GeNPs were internalized by MCF-7 cells. Their biological activity test results indicated that these Qu-GeNPs possessed stronger hydroxyl-scavenging effects and proliferative inhibition effect on MCF-7 cancer cells than quercetin, thus suggesting that the strategy to use GeNPs as a carrier of Qu could be an efficient way to achieve enhanced antioxidant and anticancer activity. In addition, Qu-GeNPs possessed a high apoptotic induction effect in cancer cells, especially in high dosages, and could arrest MCF-7 cells in the S phase.
- Subjects
QUERCETIN; GERMANIUM; NANOSTRUCTURED materials; NANOPARTICLES; POLYPHENOLS
- Publication
Chemistry - An Asian Journal, 2014, Vol 9, Issue 8, p2272
- ISSN
1861-4728
- Publication type
Article
- DOI
10.1002/asia.201402227