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- Title
THE MURINE MODEL RELEVANCE IN EXPERIMENTAL ENDOMETRIOSIS.
- Authors
Şindilar, Allia; Stan, C. I.; Şindilar, E. V.; Crauciuc, E. G.; Pînzariu, A. C.; Strat, Liliana; Zamfir, Simona Alexandra; Folescu, Roxana; Zamfir, Carmen Lăcrămioara
- Abstract
Endometriosis is considered a benign condition, in which endometrial tissue can be observed outside the uterine cavity; the chronic pelvic pain is frequently associated with infertility and may cause significant reproductive functional disorders. Animal experimental models represent an alternative for clinical studies, as a useful resource in deciphering the pathogenic mechanisms of endometriosis. MATERIAL AND METHODS: 25 adult Wistar female rats were assigned to a control group and an experimental group. A laparatomy was performed to experimental group of rats, the uterine horns were exposed and fragments from left horn were prelevated and implanted in extraperitoneal space, as ectopic implants. RESULTS: We detected the viable implant, visible as an endometriotic cyst on the abdominal wall, multiple epiploic adhesions, neovascularization areas. CONCLUSIONS: Murine model can be used with benefits for experimental research and understanding of endometriosis.
- Subjects
ENDOMETRIOSIS; PELVIC diseases
- Publication
Romanian Journal of Functional & Clinical, Macro & Microscopical Anatomy & of Anthropology / Revista Româna de Anatomie Functionala si Clinica, Macro si Microscopica si de Antropologie, 2016, Vol 15, Issue 4, p371
- ISSN
1583-4026
- Publication type
Article