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- Title
How Relevant are GFAP Autoantibodies in Autism and Tourette Syndrome?
- Authors
Kirkman, Nikki J.; Libbey, Jane E.; Sweeten, Thayne L.; Coon, Hilary H.; Miller, Judith N.; Stevenson, Edward K.; Lainhart, Janet E.; McMahon, William M.; Fujinami, Robert S.
- Abstract
Controversy exists over the role of autoantibodies to central nervous system antigens in autism and Tourette Syndrome. We investigated plasma autoantibody titers to glial fibrillary acidic protein (GFAP) in children with classic onset (33) and regressive onset (26) autism, controls (25, healthy age- and gender-matched) and individuals with Tourette Syndrome (24) by enzyme-linked immunosorbent assays. We found a significant difference in autoantibody titers to GFAP, not accounted for by age, between the Tourette (significantly lower) and regressive autism groups. However, no differences were found between: classic/regressive; classic/controls; classic/Tourette; regressive/controls; or controls/Tourette. Autoantibody responses against GFAP are unlikely to play a pathogenic role in autism or Tourette Syndrome.
- Subjects
MEDICAL research; TOURETTE syndrome; AUTISM in children; MENTAL illness; AUTISM; DEVELOPMENTAL disabilities; ANTIGENS; IMMUNOGLOBULINS; PATHOLOGICAL psychology
- Publication
Journal of Autism & Developmental Disorders, 2008, Vol 38, Issue 2, p333
- ISSN
0162-3257
- Publication type
Article
- DOI
10.1007/s10803-007-0398-9