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- Title
Measurement of free light chains with assays based on monoclonal antibodies.
- Authors
te Velthuis, Henk; Drayson, Mark; Campbell, John P.
- Abstract
Recently, serum free light chain (FLC) assays incorporating anti-kappa (κ) and anti-lambda (λ) FLC monoclonal antibodies have become available: N Latex FLC assay (Siemens) and Seralite® (Abingdon Health). The purpose of this review is to provide an overview of these two new monoclonal antibody-based methods. In doing so, the review will outline the performance characteristics of each method, including a summary of: assay principles, antibody specificity, analytical performance and assay performance in disease. Additionally, the review will describe the potential user benefiRecently, serum free light chain (FLC) assays incorporating anti-kappa (κ) and anti-lambda (λ) FLC monoclonal antibodies have become available: N Latex FLC assay (Siemens) and Seralite® (Abingdon Health). The purpose of this review is to provide an overview of these two new monoclonal antibody-based methods. In doing so, the review will outline the performance characteristics of each method, including a summary of: assay principles, antibody specificity, analytical performance and assay performance in disease. Additionally, the review will describe the potential user benefits of adopting these new generation FLC assays, which are designed to overcome the established limitations of existing polyclonal antibody based FLC assays.
- Subjects
MULTIPLE myeloma diagnosis; MONOCLONAL antibodies; BLOOD protein electrophoresis; IMMUNOASSAY; NF-kappa B; BACTERIOPHAGE lambda
- Publication
Clinical Chemistry & Laboratory Medicine, 2016, Vol 54, Issue 6, p1005
- ISSN
1434-6621
- Publication type
Article
- DOI
10.1515/cclm-2015-0963