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- Title
Type 2 diabetes, medication-induced diabetes, and monogenic diabetes in Canadian children: a prospective national surveillance study.
- Authors
Amed S; Dean HJ; Panagiotopoulos C; Sellers EA; Hadjiyannakis S; Laubscher TA; Dannenbaum D; Shah BR; Booth GL; Hamilton JK; Amed, Shazhan; Dean, Heather J; Panagiotopoulos, Constadina; Sellers, Elizabeth A C; Hadjiyannakis, Stasia; Laubscher, Tessa A; Dannenbaum, David; Shah, Baiju R; Booth, Gillian L; Hamilton, Jill K
- Abstract
<bold>Objective: </bold>To determine in Canadian children aged <18 years the 1) incidence of type 2 diabetes, medication-induced diabetes, and monogenic diabetes; 2) clinical features of type 2 diabetes; and 3) coexisting morbidity associated with type 2 diabetes at diagnosis.<bold>Research Design and Methods: </bold>This Canadian prospective national surveillance study involved a network of pediatricians, pediatric endocrinologists, family physicians, and adult endocrinologists. Incidence rates were calculated using Canadian Census population data. Descriptive statistics were used to illustrate demographic and clinical features.<bold>Results: </bold>From a population of 7.3 million children, 345 cases of non-type 1 diabetes were reported. The observed minimum incidence rates of type 2, medication-induced, and monogenic diabetes were 1.54, 0.4, and 0.2 cases per 100,000 children aged <18 years per year, respectively. On average, children with type 2 diabetes were aged 13.7 years and 8% (19 of 227) presented before 10 years. Ethnic minorities were overrepresented, but 25% (57 of 227) of children with type 2 diabetes were Caucasian. Of children with type 2 diabetes, 95% (206 of 216) were obese and 37% (43 of 115) had at least one comorbidity at diagnosis.<bold>Conclusions: </bold>This is the first prospective national surveillance study in Canada to report the incidence of type 2 diabetes in children and also the first in the world to report the incidence of medication-induced and monogenic diabetes. Rates of type 2 diabetes were higher than expected with important regional variation. These results support recommendations that screening for comorbidity should occur at diagnosis of type 2 diabetes.
- Publication
Diabetes Care, 2010, Vol 33, Issue 4, p786
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/dc09-1013