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- Title
Ultrasound Triggered Drug Release from Affinity-Based β-Cyclodextrin Polymers for Infection Control.
- Authors
Bohara, Smriti; Rohner, Nathan; Budziszewski, Emily; Suthakorn, Jackrit; von Recum, Horst A.; Exner, Agata A.
- Abstract
This work demonstrates a slow, sustained drug delivery system that provides on-demand delivery bursts through the application of pulsed therapeutic ultrasound (TUS). Insoluble β-cyclodextrin-polymer (pCD) disks were loaded with a saturated antibiotic solution of rifampicin (RIF) and used for drug delivery studies. To obtain on-demand release from the implants, TUS was applied at an intensity of 1.8 W/cm2. The therapeutic efficacy of the combination treatment was assessed in bacterial culture via an in vitro Staphylococcus aureus bioluminescence assay. The results demonstrated that the application of pulsed TUS at 3 MHz and 1.8 W/cm2 to pCD implants leads to a significantly higher short-term burst in the drug release rate compared to samples not treated with TUS. The addition of TUS increased the drug release by 100% within 4 days. The pCD disk + RIF stimulated with TUS showed a comparatively higher bacterial eradication with CFU/mL of 4.277E+09, and 8.00E+08 at 1 and 24 h compared with control treated bacteria at 1.48E+10. Overall, these results suggest that the addition of pulsed TUS could be an effective technology to noninvasively expedite antibiotic release on demand at desired intervals.
- Subjects
INFECTION control; ULTRASONIC imaging; ULTRASONIC therapy; BIOLUMINESCENCE assay; POLYMERS; MICROBUBBLE diagnosis; BIOLUMINESCENCE; DRUG delivery systems
- Publication
Annals of Biomedical Engineering, 2021, Vol 49, Issue 9, p2513
- ISSN
0090-6964
- Publication type
Article
- DOI
10.1007/s10439-021-02814-y