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- Title
Peri-Conceptional A1C and Risk of Serious Adverse Pregnancy Outcome in 933 Women With Type 1 Diabetes.
- Authors
Jensen, Dorte M.; Korsholm, Lars; Ovesen, Per; Beck-Nielsen, Henning; Moelsted-Pedersen, Lars; Westergaard, Jes G.; Moeller, Margrethe; Damm, Peter
- Abstract
OBJECTIVE -- To study the association between peri-conceptional A1C and serious adverse pregnancy outcome (congenital malformations and perinatal mortality). RESEARCH DESIGN AND METHODS-- Prospective data were collected in 933 singleton pregnancies complicated by type 1 diabetes. RESULTS-- The risk of serious adverse outcome at different A1C levels was compared with the background population. The risk was significantly higher when peri-conceptional A1C exceeded 6.9%, and the risk tended to increase gradually with increasing A1C. Women with A1C exceeding 10.4% had a very high risk of 16%. Congenital malformation rate increased significantly at A1C above 10.4%, whereas perinatal mortality was increased even at A1C below 6.9%. CONCLUSIONS-- These results support recent guidelines of preconceptional A1C levels <7% in women with type 1 diabetes.
- Subjects
GLYCOSYLATED hemoglobin; PREGNANCY complications; GESTATIONAL diabetes; HUMAN abnormalities; PERINATAL death; DIABETES in women
- Publication
Diabetes Care, 2009, Vol 32, Issue 6, p1046
- ISSN
0149-5992
- Publication type
Article
- DOI
10.2337/dc08-2061