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- Title
Antigenic profile of human melanoma cells. Analysis with monoclonal antibodies to histocompatibility antigens and to melanoma-associated antigens.
- Authors
Natali, P. G.; Giacomini, P.; Russo, C.; Steinbach, G.; Fenoglio, C.; Ferrone, S.
- Abstract
The possible role played by immunological factors in the pathogenesis and clinical course of malignant diseases has stimulated interest in the characterization of antigenic changes associated with malignant transformation of human cells. The article discusses the development of hybridoma technology. In this procedure, antibody-secreting lymphocytes are hybridized with myeloma cells carrying an enzymatic defect which allows their selective destruction in an appropriate culture medium. Hybridomas secreting antibodies with the desired specificity are identified and used as an unlimited source of monoclonal antibodies.
- Subjects
EPITOPES; HYBRIDOMAS; MONOCLONAL antibodies; IMMUNOSPECIFICITY; MELANOMA; IMMUNOGLOBULINS
- Publication
Journal of Cutaneous Pathology, 1983, Vol 10, Issue 4, p225
- ISSN
0303-6987
- Publication type
Article
- DOI
10.1111/j.1600-0560.1983.tb01489.x