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- Title
Genome-wide association study of chronic periodontitis in a general German population.
- Authors
Teumer, Alexander; Holtfreter, Birte; Völker, Uwe; Petersmann, Astrid; Nauck, Matthias; Biffar, Reiner; Völzke, Henry; Kroemer, Heyo K.; Meisel, Peter; Homuth, Georg; Kocher, Thomas
- Abstract
Aim To identify loci associated with chronic periodontitis through a genome-wide association study ( GWAS). Materials and Methods A GWAS was performed in 4032 individuals of two independent cross-sectional studies of West Pomerania ( SHIP n = 3365 and SHIP- TREND n = 667) with different periodontal case definitions. Samples were genotyped with the Affymetrix Genome-Wide Human SNP Array 6.0 or the Illumina Human Omni 2.5 array. Imputation of the HapMap as well as the 1000 Genome-based autosomal and X-chromosomal genotypes and short insertions and deletions ( INDELs) was performed in both cohorts. Finally, more than 17 million SNPs and short INDELs were analysed. Results No genome-wide significant associations were found for any periodontitis case definition, regardless of whether individuals aged >60 years where excluded or not. Despite no single SNP association reached genome-wide significance, the proportion of variance explained by additive effects of all common SNPs was around 23% for mean proximal attachment loss. Excluding subjects aged >60 years increased the explained variance to 34%. Conclusions No single SNPs were found to be genome-wide significantly associated with chronic periodontitis in this study.
- Subjects
GERMANY; PERIODONTITIS; ACADEMIC medical centers; ANALYSIS of variance; CHI-squared test; CONFIDENCE intervals; EPIDEMIOLOGY; GENES; HEALTH outcome assessment; REGRESSION analysis; RESEARCH funding; DATA analysis; EQUIPMENT &; supplies; DATA analysis software; DESCRIPTIVE statistics; GENETICS
- Publication
Journal of Clinical Periodontology, 2013, Vol 40, Issue 11, p977
- ISSN
0303-6979
- Publication type
Article
- DOI
10.1111/jcpe.12154