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- Title
Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [<sup>99m</sup>Tc] TRODAT-1.
- Authors
Chang, Ting Ting; Yeh, Tzung Lieh; Chiu, Nan Tsing; Chen, Po See; Huang, Hsiang Yu; Yang, Yen Kuang; Lee, I Hui; Lu, Ru Band
- Abstract
Chang TT, Yeh TL, Chiu NT, Chen PS, Huang HY, Yang YK, Lee IH, Lu RB. Higher striatal dopamine transporters in euthymic patients with bipolar disorder: a SPECT study with [99mTc] TRODAT-1. Bipolar Disord 2010: 12: 102–106. © 2010 The Authors. Journal compilation © 2010 John Wiley & Sons A/S. Objectives: Dopamine has been implicated in the etiology of bipolar disorder. The aim of this study was to explore striatal dopamine transporter (DAT) availability in euthymic bipolar patients. Methods: Seventeen drug-free euthymic bipolar patients were recruited. The availability of DAT was approximated using single photon emission computed tomography (SPECT) with [99mTc] TRODAT-1. Results: Compared to the controls, the euthymic bipolar patients had significantly higher availability of striatal DAT. Conclusions: Even for patients in the euthymic state, the DAT availability is still higher than that of the controls.
- Subjects
DOPAMINE; BIPOLAR disorder; ETIOLOGY of diseases; PEOPLE with bipolar disorder; TOMOGRAPHY
- Publication
Bipolar Disorders, 2010, Vol 12, Issue 1, p102
- ISSN
1398-5647
- Publication type
Article
- DOI
10.1111/j.1399-5618.2009.00771.x