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- Title
Maternal history of recurrent pregnancy loss is associated with increased risk for long‐term pediatric gastrointestinal morbidity in the offspring.
- Authors
Lichtman, Yael; Sheiner, Eyal; Wainstock, Tamar; Segal, Idit; Landau, Daniella; Walfisch, Asnat
- Abstract
Problem: Recurrent pregnancy loss (RPL) potentially involves an abnormal maternal inflammatory response. We investigated whether children of mothers with a history of RPL are at an increased risk for childhood gastrointestinal (GI) morbidity, with a specific focus on inflammatory bowel diseases (IBD). Method of study: A population‐based cohort analysis comparing the risk for long‐term GI morbidity in children born to mothers with and without a history of RPL. Gastrointestinal (GI) morbidity included hospitalizations involving a pre‐defined set of ICD‐9 codes. Results: During the study period, 242 186 newborns met the inclusion criteria; 5% of which were offspring to mothers with a history of RPL. Gastrointestinal morbidity was significantly more common in the RPL group (6.6% vs 5.3%). Specifically, offspring to mothers with a history of RPL had significantly higher rates of IBD (2.1% vs 1.7%). Conclusion: Maternal history of RPL is associated with an increased risk for pediatric GI morbidity in the offspring.
- Subjects
RECURRENT miscarriage; INFLAMMATORY bowel diseases; JUVENILE diseases; GASTROINTESTINAL diseases; HISTORY of medicine; DISEASE susceptibility; AUTOIMMUNE diseases; DISEASE risk factors
- Publication
American Journal of Reproductive Immunology, 2018, Vol 79, Issue 2, p1
- ISSN
1046-7408
- Publication type
Article
- DOI
10.1111/aji.12799