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- Title
Modelling the optimal dosing schedule for artemether-lumefantrine chemoprophylaxis against malaria.
- Authors
Tarning, Joel; von Seidlein, Lorenz; Dondorp, Arjen M.; White, Nicholas J.; Maude, Richard J.
- Abstract
Objective: Antimalarial chemoprophylaxis for high risk groups in endemic areas of Southeast Asia has the potential to reduce malaria transmission and accelerate elimination. However, the optimal choice of medication and dosing for many potential candidates is not clear. For a planned randomised controlled trial of prophylaxis for forest goers in Cambodia, artemether-lumefantrine (AL) was selected because of its ongoing efficacy and excellent tolerability and safety. As AL had not been used before for this purpose, a previously published pooled pharmacometric meta-model was used to determine the optimal dosing schedule. Results: A full 3 day AL treatment course given twice a month, and twice daily treatment given once a week, resulted in trough concentrations consistently above the therapeutic threshold of 200 ng/mL. However, the most favourable exposure profile, and arguably most practical dosing scenario, was an initial 3 day full AL treatment course followed by twice daily dosing given once a week for the duration of chemoprevention. The latter was adopted as the dosing schedule for the trial.
- Subjects
SOUTHEAST Asia; CAMBODIA; MALARIA; CHEMOPREVENTION; RANDOMIZED controlled trials; SCHEDULING
- Publication
BMC Research Notes, 2022, Vol 15, Issue 1, p1
- ISSN
1756-0500
- Publication type
Article
- DOI
10.1186/s13104-022-06212-y