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- Title
Impact of measurement method on interobserver variability of apparent diffusion coefficient of lesions in prostate MRI.
- Authors
Takahashi, Hiroaki; Yoshida, Kotaro; Kawashima, Akira; Lee, Nam Ju; Froemming, Adam T.; Adamo, Daniel A.; Khandelwal, Ashish; Bolan, Candice W.; Heller, Matthew T.; Hartman, Robert P.; Kim, Bohyun; Philbrick, Kenneth A.; Carter, Rickey E.; Mynderse, Lance A.; Humphreys, Mitchell R.; Cai, Jason C.; Takahashi, Naoki
- Abstract
Purpose: To compare the inter-observer variability of apparent diffusion coefficient (ADC) values of prostate lesions measured by 2D-region of interest (ROI) with and without specific measurement instruction. Methods: Forty lesions in 40 patients who underwent prostate MR followed by targeted prostate biopsy were evaluated. A multi-reader study (10 readers) was performed to assess the agreement of ADC values between 2D-ROI without specific instruction and 2D-ROI with specific instruction to place a 9-pixel size 2D-ROI covering the lowest ADC area. The computer script generated multiple overlapping 9-pixel 2D-ROIs within a 3D-ROI encompassing the entire lesion placed by a single reader. The lowest mean ADC values from each 2D-small-ROI were used as reference values. Inter-observer agreement was assessed using the Bland-Altman plot. Intraclass correlation coefficient (ICC) was assessed between ADC values measured by 10 readers and the computer-calculated reference values. Results: Ten lesions were benign, 6 were Gleason score 6 prostate carcinoma (PCa), and 24 were clinically significant PCa. The mean±SD ADC reference value by 9-pixel-ROI was 733 ± 186 (10−6 mm2/s). The 95% limits of agreement of ADC values among readers were better with specific instruction (±112) than those without (±205). ICC between reader-measured ADC values and computer-calculated reference values ranged from 0.736–0.949 with specific instruction and 0.349–0.919 without specific instruction. Conclusion: Interobserver agreement of ADC values can be improved by indicating a measurement method (use of a specific ROI size covering the lowest ADC area).
- Subjects
ENDORECTAL ultrasonography; DIFFUSION coefficients; PROSTATE; INTRACLASS correlation; REFERENCE values; BLAND-Altman plot
- Publication
PLoS ONE, 2022, Vol 17, Issue 5, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0268829