We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Invasive Trichoderma spp. infections: clinical presentation and outcome of cases from the literature and the FungiScope® registry.
- Authors
Sal, Ertan; Stemler, Jannik; Salmanton-García, Jon; Falces-Romero, Iker; Kredics, László; Meyer, Elisabeth; Würstl, Benjamin; Lass-Flörl, Cornelia; Racil, Zdenek; Klimko, Nikolay; Cesaro, Simone; Kindo, Anupma Jyoti; Wisplinghoff, Hilmar; Koehler, Philipp; Cornely, Oliver A; Seidel, Danila
- Abstract
<bold>Background: </bold>Trichoderma spp. are filamentous fungi causing invasive fungal diseases in patients with haematological malignancies and in peritoneal dialysis patients.<bold>Objectives: </bold>To analyse clinical presentation, predisposing factors, treatment and outcome of Trichoderma infections.<bold>Methods: </bold>A systematic literature review was conducted for published cases of invasive Trichoderma infection in PubMed until December 2021 and by reviewing the included studies' references. Cases from the FungiScope® registry were added to a combined analysis.<bold>Results: </bold>We identified 50 invasive infections due to Trichoderma species, including 11 in the FungiScope® registry. The main underlying conditions were haematological malignancies in 19 and continuous ambulatory peritoneal dialysis (CAPD) in 10 cases. The most prevalent infection sites were lung (42%) and peritoneum (22%). Systemic antifungal therapy was administered in 42 cases (84%), mostly amphotericin B (n = 27, lipid-based formulation 13/27) and voriconazole in 15 cases (30%). Surgical interventions were performed in 13 cases (26%). Overall mortality was 48% (n = 24) and highest for allogeneic HSCT and solid organ transplantation (SOT) recipients [80% (4/5) and 77% (7/9), respectively]. In patients treated with amphotericin B, voriconazole and caspofungin, mortality was 55% (15/27), 46% (7/15) and 28% (2/7), respectively. Three out of four patients treated with a combination therapy of voriconazole and caspofungin survived.<bold>Conclusions: </bold>Despite treatment with antifungal therapies and surgery, invasive Trichoderma infections are life-threatening complications in immunocompromised patients, especially after HSCT and SOT. In addition, Trichoderma spp. mainly affect the lungs in patients with haematological malignancies and the peritoneum in CAPD patients.
- Subjects
ANTIFUNGAL agents; VORICONAZOLE; AMPHOTERICIN B; FUNGI; ACQUISITION of data; HEMATOLOGIC malignancies; RESEARCH funding; DISEASE complications
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2022, Vol 77, Issue 10, p2850
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkac235