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- Title
Microbiological efficacy and tolerability of a single-dose regimen of 1 g of ceftriaxone in men with gonococcal urethritis.
- Authors
Shin Ito; Mitsuru Yasuda; Kyoko Hatazaki; Kosuke Mizutani; Tomohiro Tsuchiya; Shigeaki Yokoi; Masahiro Nakano; Takashi Deguchi; Ito, Shin; Yasuda, Mitsuru; Hatazaki, Kyoko; Mizutani, Kosuke; Tsuchiya, Tomohiro; Yokoi, Shigeaki; Nakano, Masahiro; Deguchi, Takashi
- Abstract
<bold>Objectives: </bold>We treated men with gonococcal urethritis with a single-dose regimen of 1 g of ceftriaxone, which is recommended as the first-line treatment for gonorrhoea in Japan, to determine its microbiological outcomes and tolerability.<bold>Methods: </bold>We enrolled 255 men with gonococcal urethritis and treated them with a single-dose regimen of 1 g of ceftriaxone. We evaluated its microbiological outcomes and tolerability. We also determined ceftriaxone MICs for pretreatment isolates of Neisseria gonorrhoeae collected from the patients.<bold>Results: </bold>The microbiological efficacy of the ceftriaxone regimen, which was determined between 5 and 9 days after treatment in 111 men based on the Japanese guideline for clinical research on antimicrobial agents in urogenital infections, was 100%. In the 194 men who returned to the clinic between 2 and 41 days after treatment, 191 (98.5%; 95% CI 96.8%-100%) were negative for N. gonorrhoeae after treatment. Ceftriaxone MICs determined for 136 pretreatment isolates obtained from these 194 men ranged from 0.001 to 0.25 mg/L. One isolate persisting after treatment exhibited a ceftriaxone MIC of 0.008 mg/L. For two isolates persisting after treatment, ceftriaxone MICs were not determined. Seven adverse events were observed in 7 (3.2%) of the 220 men treated with the ceftriaxone regimen. Four men had diarrhoea classified as grade 1. Three had urticaria during ceftriaxone administration, with one event classified as grade 1 and two events classified as grade 3.<bold>Conclusions: </bold>A single-dose regimen of 1 g of ceftriaxone was microbiologically effective against gonococcal urethritis and was safe and tolerable.
- Subjects
JAPAN; GONORRHEA treatment; CEFTRIAXONE; URETHRITIS; ANTI-infective agents; MICROBIOLOGY; ANTIBIOTICS; DRUG side effects; GONORRHEA; MICROBIAL sensitivity tests; NEISSERIA; TREATMENT effectiveness
- Publication
Journal of Antimicrobial Chemotherapy (JAC), 2016, Vol 71, Issue 9, p2559
- ISSN
0305-7453
- Publication type
journal article
- DOI
10.1093/jac/dkw180