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- Title
Palladium-Catalyzed Base-Promoted Arylation of Unactivated C(sp<sup>3</sup>)-H Bonds by Aryl Iodides: A Practical Approach To Synthesize β-Aryl Carboxylic Acid Derivatives.
- Authors
Gou, Quan; Liu, Gang; Zhou, Lanxiu; Chen, Suiyun; Qin, Jun
- Abstract
A highly efficient protocol for the β-arylation of carboxylic amides by aryl iodides under PdCl2(CH3CN)2/CsOAc catalysis was developed. This method was found to tolerate a broad scope of substrates and was successfully employed in the preparation of a variety of β-aryl α-amino and γ-amino acid derivatives. The utility of this method was further illustrated in the synthesis of the psychotropic drug (±)-phenibut and β-aryl bile acid analogues.
- Subjects
PALLADIUM catalysts; ARYLATION; AMINO acid derivatives; ARYL iodides; CARBOXYLIC acid derivatives
- Publication
European Journal of Organic Chemistry, 2017, Vol 2017, Issue 42, p6314
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201701215