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- Title
TBHP/CoCl<sub>2</sub>-Mediated Intramolecular Oxidative Cyclization of N-(2-Formylphenyl)amides: An Approach to the Construction of 4 H-3,1-Benzoxazin-4-ones.
- Authors
Yu, Junchao; Zhang‐Negrerie, Daisy; Du, Yunfei
- Abstract
The intramolecular oxidative cyclization of N-(2-formylphenyl)amides has been realized through an oxidative C(sp2)-O(sp2) bond-forming reaction between an aldehyde carbon and amide oxygen. This new strategy, which uses tert-butyl hydroperoxide (TBHP) as an oxidant and CoCl2 as the catalyst, allows for the efficient Co-catalyzed synthesis of useful benzoxazin-4-one derivatives and features readily available starting materials and mild reaction conditions.
- Subjects
AMIDE derivatives; ALDEHYDE derivatives; HYDROPEROXIDES; COBALT chloride; OXIDATION; RING formation (Chemistry); BENZOXAZINONES; BUTYL group
- Publication
European Journal of Organic Chemistry, 2016, Vol 2016, Issue 3, p562
- ISSN
1434-193X
- Publication type
Article
- DOI
10.1002/ejoc.201501359