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- Title
Prevalence of iron deficiency anemia and beta thalassemia carriers among relatives of beta thalassemia patients in Nile Delta region, Egypt: a multicenter study.
- Authors
El-Shanshory, Mohamed R.; Sherief, Laila M.; Hassab, Hoda M.; Ragab, Seham M.; Yahia, Sohier; Mansour, Ahmed K.; Ahmed, Adel S.; Abdou, Said H.; Helmy, Amal M.; Watany, Mona M.; Gad ALllah, Ahmed M.; Guindy, Myriam A.; Mourad, Zeinab I.; Soliman, Mohamed A.; El-Farahaty, Reham M.; El-Dahtory, Faeza; Darwish, Ahmad; Elmabood, Suzy Abd; Kabbash, Ibrahim A.; Saied, Shimaa M.
- Abstract
Background: Screening of β thalassemia among close relatives is more feasible in highly prevalent countries with limited resources. The purpose of this study is to determine the prevalence of β thalassemia carriers and iron deficiency anemia among relatives of β thalassemia patients in Mid Delta, Egypt. Methods: This is a cross-sectional multi-center study conducted on 2118 relatives of patients with β thalassemia from different Egyptian governorates in the Mid Delta region. They were subjected to history taking with precise determination of geographic location, general examination, and the following investigations: complete blood counts, serum ferritin for those who showed microcytic hypochromic anemia, and high-performance liquid chromatography for those who were not diagnosed as iron deficiency anemia. Results: The total prevalence of iron deficiency anemia among close relatives of confirmed β thalassemia patients in the Nile Delta region was 17.19%. The highest prevalence of iron deficiency anemia (45.05%) was reported in Al-Gharbia Governorate, followed by Al-Menoufia Governorate (21.67%), and the lowest prevalence was that of Al-Sharkia Governorate (4.91%). The differences were highly statistically significant (p < 0.001). β thalassemia carrier prevalence rate in the studied relatives was 35.84%, with the highest prevalence detected in Al-Sharkia Governorate (51.32%), followed by Kafr-Alsheikh and Al-Dakahilia Governorates (41.78%, 37.13%) respectively, while Al-Menoufia Governorate had the lowest prevalence rate (25.00%). These differences were also highly statistically significant (p < 0.001). Conclusion: More than one-third of relatives of patients with β thalassemia are carriers of the disease, while 17.19% suffer from iron deficiency anemia. This study demonstrates the importance of tracing the high number of beta thalassemia carriers among relatives of patients with β thalassemia in Egypt.
- Subjects
EGYPT; NILE River Delta (Egypt); IRON deficiency anemia; BETA-Thalassemia; HIGH performance liquid chromatography; BLOOD cell count; DISEASE vectors; MUMMIES
- Publication
Journal of the Egyptian Public Health Association, 2021, Vol 96, Issue 1, p1
- ISSN
0013-2446
- Publication type
Article
- DOI
10.1186/s42506-021-00088-9