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- Title
Better Adherence with Once-Daily Antiretroviral Regimens: A Meta-Analysis.
- Authors
Parienti, Jean-Jacques; Bangsberg, David R.; Verdon, Renaud; Gardner, Edward M.
- Abstract
Once-daily regimens of antiretroviral therapy are simpler than other regimens, but whether such regimens are associated with better adherence to treatment is controversial. We performed a meta-analysis of 11 randomized, controlled trials (total number of subjects, 3029), which revealed that the adherence rate was better with once-daily regimens (+ 2.9%; 95% confidence interval, 1.0%-4.8%; P < .003) than with twice-daily regimens. This modest effect was more pronounced at the time of treatment initiation and for regimens for which all medications were taken once per day.
- Subjects
ANTIVIRAL agents; PATIENT compliance; CLINICAL trials; RANDOMIZED controlled trials; HEALTH behavior; MEDICAL cooperation
- Publication
Clinical Infectious Diseases, 2009, Vol 48, Issue 4, p484
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/596482