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- Title
HPA axis normalization, estimated by DEX/CRH test, but less alteration on cerebral glucose metabolism in depressed patients receiving ECT after medication treatment failures.
- Authors
Yuuki, N.; Ida, I.; Oshima, A.; Kumano, H.; Takahashi, K.; Fukuda, M.; Oriuchi, N.; Endo, K.; Matsuda, H.; Mikuni, M.
- Abstract
Objective: To examine the clinical effects of electroconvulsive therapy (ECT) on depressed patients with medication treatment failures, we investigated the alterations in hypothalamic-pituitary-adrenocortical (HPA) function and regional cerebral metabolism rate of glucose (rCMRGlu) after ECT in these patients. Method: Before and after ECT, the combined dexamethasone/corticotrophin-releasing hormone (DEX/CRH) test was administered to seven patients who were referred for ECT. In the same patients, 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) was also assessed. Results: Cortisol response in the DEX/CRH test significantly decreased after a successful ECT. A significant hypometabolism in various frontal regions and hypermetabolism in the parietal regions of these patients when compared with controls remained after ECT. Conclusion: Depressed patients who failed trials of antidepressant medication showed a remission with ECT that was accompanied by resolution of HPA dysregulation. However, measures of cerebral brain metabolism did not resolve.
- Subjects
ELECTROCONVULSIVE therapy; CORTICOTROPIN releasing hormone; HYPOTHALAMIC-pituitary-adrenal axis; POSITRON emission tomography; DEPRESSED persons; MENTAL health; PSYCHIATRY
- Publication
Acta Psychiatrica Scandinavica, 2005, Vol 112, Issue 4, p257
- ISSN
0001-690X
- Publication type
Article
- DOI
10.1111/j.1600-0447.2005.00625.x