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- Title
Regulation of TRPML1 function.
- Authors
Waller-Evans, Helen; Lloyd-Evans, Emyr
- Abstract
TRPML1 is a ubiquitously expressed cation channel found on lysosomes and late endosomes. Mutations in TRPML1 cause mucolipidosis type IV and it has been implicated in Alzheimer's disease and HIV. However, the mechanisms by which TRPML1 activity is regulated are not well understood. This review summarizes the current understanding of TRPML1 activation and regulation.
- Subjects
ALZHEIMER'S disease; LYSOSOMES; MUCOLIPINS; HIV infections; ENDOSOMES; GENETIC mutation; BIOCHEMICAL mechanism of action
- Publication
Biochemical Society Transactions, 2015, Vol 43, Issue 3, p442
- ISSN
0300-5127
- Publication type
Article
- DOI
10.1042/BST20140311