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- Title
Preclinical Models for Skeletal Research: How Commonly Used Species Mimic (or Don’t) Aspects of Human Bone.
- Authors
Allen, Matthew R.
- Abstract
Preclinical studies play an indispensable role in exploring the biological regulation of the musculoskeletal system. They are required in all drug development pipelines where both small and large animal models are needed to understand efficacy and side effects. This brief review highlights 4 aspects of human bone, longitudinal bone growth, intracortical remodeling, collagen/mineral interface, and age-related changes, and discusses how various animal models recapitulate (or don’t) these aspects of human skeletal physiology.
- Subjects
MUSCULOSKELETAL system; BONE growth; DRUG efficacy
- Publication
Toxicologic Pathology, 2017, Vol 45, Issue 7, p851
- ISSN
0192-6233
- Publication type
Article
- DOI
10.1177/0192623317733925