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- Title
Structural plasticity of the ventral stream and aphasia recovery.
- Authors
McKinnon, Emilie T.; Fridriksson, Julius; Glenn, G. Russell; Jensen, Jens H.; Helpern, Joseph A.; Basilakos, Alexandra; Rorden, Chris; Shih, Andy Y.; Spampinato, M. Vittoria; Bonilha, Leonardo
- Abstract
Restrengthening of the residual language network is likely to be crucial for speech recovery in poststroke aphasia. Eight participants with chronic aphasia received intensive speech therapy for 3 weeks, with standardized naming tests and brain magnetic resonance imaging before and after therapy. Kurtosis-based diffusion tensor tractography was used to measure mean kurtosis (MK) along a segment of the inferior longitudinal fasciculus (ILF). Therapy-related reduction in the number of semantic but not phonemic errors was associated with strengthening (renormalization) of ILF MK (r = -0.90, p < 0.05 corrected), suggesting that speech recovery is related to structural plasticity of language-specific components of the residual language network. Ann Neurol 2017;82:147-151.
- Subjects
APHASIA; NEUROPLASTICITY; DIFFUSION tensor imaging; SPEECH therapy; KURTOSIS; CLINICAL trials; COMPARATIVE studies; MAGNETIC resonance imaging; RESEARCH methodology; MEDICAL cooperation; NEURORADIOLOGY; OCCIPITAL lobe; RESEARCH; TEMPORAL lobe; EVALUATION research; NEURAL pathways; THERAPEUTICS
- Publication
Annals of Neurology, 2017, Vol 82, Issue 1, p147
- ISSN
0364-5134
- Publication type
journal article
- DOI
10.1002/ana.24983