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- Title
Comparison of Diabetic Patients with Different Manifestations of Atherosclerosis with Respect to Clinical Characteristics, Biochemical Parameters and Medication -- Results from the REACH Registry.
- Authors
Parhofer, Klaus G.; Zeymer, Uwe; Stark, Renee G.; Röther, Joachim
- Abstract
Atherothrombosis can present as coronary artery disease (CAD), cerebrovascular disease (CVD) and peripheral arterial disease (PAD). It is unknown whether diabetic patients with CAD differ from those with CVD or PAD regarding clinical characteristics, biochemical parameters and medication. The REACH (REduction of Atherothrombosis for Continued Health) Registry contains data on over 68,000 patients with atherosclerosis or risk factors. The registry's primary goal is to evaluate vascular endpoints. In total, 5646 patients were recruited in Germany, 2390 (42%) of which are diabetic. Of these, 852 (36%) have only CAD, 286 (12%) have only CVD and 176 (7%) have only PAD. The others have either only risk factors (18%) or multiple manifestations (27%). The baseline data of diabetic patients (80% male, 68 ± 9 years, BMI 129 ± 5 kg/m²) with only CAD, or CVD, or PAD were evaluated (generalized linear model for continuous dependent variables, logistic regression for dependent variables with 2 classes; SAS). After correcting for age, sex and BMI, CAD patients receive (OR; 95% CI) statins (4.1; 2.9-5.9), beta-blockers (4.1; 4.9-10.5), diuretics (1.9; 1.3-2.6) and nitrates (8.7; 4.5-16.8) significantly more frequently and significantly less calcium-antagonists (0.73; 0.55-0.98). There was no difference concerning other antihypertensives, antidiabetics and platelet inhibitors. Medication differences resulted in significant ((*) p<0.05) differences between CAD compared to CVD and PAD regarding clinical and laboratory parameters (Table). Overall only few patients (CAD 9.5%, CVD 8.5%, PAD 0%) reach all treatment goals (BP-systolic ≤130mmHg, BP-diastolic ≤85mmHg, LDL≤100mg/dl, HDL≥40mg/dl, triglycerides ≤150mg/dl). These data indicate considerable differences in therapy between diabetics with CAD compared to those with CVD or PAD. Diabetics with CAD are treated more aggressively and therefore reach lower lipid values and lower blood pressure values.
- Subjects
GERMANY; ATHEROSCLEROSIS; PEOPLE with diabetes; CORONARY disease; CEREBROVASCULAR disease; TREATMENT of diabetes
- Publication
Diabetes, 2007, Vol 56, pA170
- ISSN
0012-1797
- Publication type
Article