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- Title
No Time to Relax and Unwind: Exploration of Topoisomerases and a Growing Field of Study.
- Authors
Deweese, Joseph E.; Osheroff, Neil
- Abstract
With the topoisomerase field in its sixth decade [[1]], it is worth taking a moment to pause and consider where our knowledge has come from and where the field is headed. With the approval of antibody-drug conjugates targeting topoisomerase I, there is renewed interest in identifying novel compounds and understanding the mechanisms of topoisomerase-targeted anticancer agents [[9]]. Methods such as Hi-C that helped map interactions between and within chromosomes could be combined with topoisomerase binding maps to provide a more genome-wide vision of topoisomerase function [[15]].
- Subjects
DNA topoisomerase I; DNA topoisomerase II; NUCLEIC acids; COVID-19 pandemic; DNA topoisomerases; DATA libraries
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 17, p13080
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms241713080