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- Title
New Monoterpenoid Indole Alkaloids from Tabernaemontana crassa Inhibit β -Amyloid42 Production and Phospho-Tau (Thr217).
- Authors
Li, Sheng; Han, Ling-Ling; Huang, Ke-Pu; Ma, Ye-Han; Guo, Ling-Li; Guo, Yarong; Ran, Xiaoqian; Yao, Yong-Gang; Hao, Xiao-Jiang; Luo, Rongcan; Zhang, Yu
- Abstract
Eleven monoterpenoid indole alkaloids, including three new ones, tabercrassines A–C (1–3), were isolated from the seeds of Tabernaemontana crassa. Tabercrassine A (1) is an ibogan–ibogan-type bisindole alkaloid which is formed by the polymerization of two classic ibogan-type monomers through a C3 unit aliphatic chain. Their structures were established by extensive analysis of HRESIMS, NMR, and ECD spectra. Cellular assays showed that alkaloids 1–3 all reduce Aβ42 production and inhibit phospho-tau (Thr217), a new biomarker of Alzheimer's disease [AD] associated with BACE1-, NCSTN-, GSK3β-, and CDK5-mediated pathways, suggesting these alkaloids' potential against AD.
- Subjects
INDOLE alkaloids; MONOTERPENOIDS; TABERNAEMONTANA; ALZHEIMER'S disease; TAU proteins; MONOMERS; ISOQUINOLINE alkaloids; ALKALOIDS
- Publication
International Journal of Molecular Sciences, 2023, Vol 24, Issue 2, p1487
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms24021487