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- Title
Enhancement of Immune Checkpoint Inhibitor-Mediated Anti-Cancer Immunity by Intranasal Treatment of Ecklonia cava Fucoidan against Metastatic Lung Cancer.
- Authors
Zhang, Wei; Hwang, Juyoung; Yadav, Dhananjay; An, Eun-Koung; Kwak, Minseok; Lee, Peter Chang-Whan; Jin, Jun-O
- Abstract
Although fucoidan, a well-studied seaweed-extracted polysaccharide, has shown immune stimulatory effects that elicit anticancer immunity, mucosal adjuvant effects via intranasal administration have not been studied. In this study, the effect of Ecklonia cava-extracted fucoidan (ECF) on the induction of anti-cancer immunity in the lung was examined by intranasal administration. In C57BL/6 and BALB/c mice, intranasal administration of ECF promoted the activation of dendritic cells (DCs), natural killer (NK) cells, and T cells in the mediastinal lymph node (mLN). The ECF-induced NK and T cell activation was mediated by DCs. In addition, intranasal injection with ECF enhanced the anti-PD-L1 antibody-mediated anti-cancer activities against B16 melanoma and CT-26 carcinoma tumor growth in the lungs, which were required cytotoxic T lymphocytes and NK cells. Thus, these data demonstrated that ECF functioned as a mucosal adjuvant that enhanced the immunotherapeutic effect of immune checkpoint inhibitors against metastatic lung cancer.
- Subjects
IMMUNE checkpoint proteins; INTRANASAL administration; LUNG cancer; CYTOTOXIC T cells; METASTASIS; KILLER cells; LUNGS; T cells
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 17, p9125
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22179125