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- Title
Molecular Chaperones and miRNAs in Epilepsy: Pathogenic Implications and Therapeutic Prospects.
- Authors
Zummo, Leila; Vitale, Alessandra Maria; Caruso Bavisotto, Celeste; De Curtis, Marco; Garbelli, Rita; Giallonardo, Anna Teresa; Di Bonaventura, Carlo; Fanella, Martina; Conway de Macario, Everly; Cappello, Francesco; Macario, Alberto J. L.; Marino Gammazza, Antonella
- Abstract
Epilepsy is a pathologic condition with high prevalence and devastating consequences for the patient and its entourage. Means for accurate diagnosis of type, patient monitoring for predicting seizures and follow up, and efficacious treatment are desperately needed. To improve this adverse outcome, miRNAs and the chaperone system (CS) are promising targets to understand pathogenic mechanisms and for developing theranostics applications. miRNAs implicated in conditions known or suspected to favor seizures such as neuroinflammation, to promote epileptic tolerance and neuronal survival, to regulate seizures, and others showing variations in expression levels related to seizures are promising candidates as useful biomarkers for diagnosis and patient monitoring, and as targets for developing novel therapies. Components of the CS are also promising as biomarkers and as therapeutic targets, since they participate in epileptogenic pathways and in cytoprotective mechanisms in various epileptogenic brain areas, even if what they do and how is not yet clear. The data in this review should help in the identification of molecular targets among the discussed miRNAs and CS components for research aiming at understanding epileptogenic mechanisms and, subsequently, develop means for predicting/preventing seizures and treating the disease.
- Subjects
MICRORNA; EPILEPSY; DRUG target; TEMPORAL lobe epilepsy; DIAGNOSIS; NEUROCYSTICERCOSIS
- Publication
International Journal of Molecular Sciences, 2021, Vol 22, Issue 16, p8601
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms22168601