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- Title
Investigation of a Staphylococcus argenteus Strain Involved in a Chronic Prosthetic-Joint Infection.
- Authors
Diot, Alan; Dyon-Tafani, Virginie; Bergot, Marine; Tasse, Jason; Martins-Simões, Patricia; Josse, Jérôme; Valour, Florent; Laurent, Frédéric
- Abstract
Staphylococcus argenteus is an emerging species responsible for infections comparable to those induced by Staphylococcus aureus. It has been involved in few chronic or persistent infections so far. In this study, we described a case of a persistent prosthetic-joint infection (PJI) affecting a young woman. We investigated in vitro the virulence traits of the incriminated S. argenteus strain (bone cell invasion, biofilm formation and induction of inflammation) and analyzed its genome, in comparison with two other strains of S. argenteus and two S. aureus isolates. It appeared that this S. argenteus PJI strain combined biofilm formation, osteoblast invasion and intracellular persistence abilities together with genes potentially involved in the escape of the host immune defenses, which might explain the chronicization of the infection.
- Subjects
STAPHYLOCOCCUS; STAPHYLOCOCCUS aureus; BONE cells; YOUNG women; INFECTION
- Publication
International Journal of Molecular Sciences, 2020, Vol 21, Issue 17, p6245
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms21176245