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- Title
Mechanisms and Functions of Long Non-Coding RNAs at Multiple Regulatory Levels.
- Authors
Zhang, Xiaopei; Wang, Wei; Zhu, Weidong; Dong, Jie; Cheng, Yingying; Yin, Zujun; Shen, Fafu
- Abstract
Long non-coding (lnc) RNAs are non-coding RNAs longer than 200 nt. lncRNAs primarily interact with mRNA, DNA, protein, and miRNA and consequently regulate gene expression at the epigenetic, transcriptional, post-transcriptional, translational, and post-translational levels in a variety of ways. They play important roles in biological processes such as chromatin remodeling, transcriptional activation, transcriptional interference, RNA processing, and mRNA translation. lncRNAs have important functions in plant growth and development; biotic and abiotic stress responses; and in regulation of cell differentiation, the cell cycle, and the occurrence of many diseases in humans and animals. In this review, we summarize the functions and mechanisms of lncRNAs in plants, humans, and animals at different regulatory levels.
- Subjects
NON-coding RNA; CHROMATIN-remodeling complexes; CELLULAR control mechanisms; PLANT development; CELL differentiation; ANIMAL diseases; CELL cycle regulation
- Publication
International Journal of Molecular Sciences, 2019, Vol 20, Issue 22, p5573
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms20225573