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- Title
How Tyramine β-Hydroxylase Controls the Production of Octopamine, Modulating the Mobility of Beetles.
- Authors
Xu, Li; Jiang, Hong-Bo; Chen, Xiao-Feng; Xiong, Ying; Lu, Xue-Ping; Pei, Yu-Xia; Smagghe, Guy; Wang, Jin-Jun
- Abstract
Biogenic amines perform many kinds of important physiological functions in the central nervous system (CNS) of insects, acting as neuromodulators, neurotransmitters, and neurohormones. The five most abundant types of biogenic amines in invertebrates are dopamine, histamine, serotonin, tyramine, and octopamine (OA). However, in beetles, an important group of model and pest insects, the role of tyramine β-hydroxylase (TβH) in the OA biosynthesis pathway and the regulation of behavior remains unknown so far. We therefore investigated the molecular characterization and spatiotemporal expression profiles of TβH in red flour beetles (Triboliun castaneum). Most importantly, we detected the production of OA and measured the crawling speed of beetles after dsTcTbH injection. We concluded that TcTbH controls the biosynthesis amount of OA in the CNS, and this in turn modulates the mobility of the beetles. Our new results provided basic information about the key genes in the OA biosynthesis pathway of the beetles, and expanded our knowledge on the physiological functions of OA in insects.
- Subjects
TYRAMINE; OCTOPAMINE; BIOGENIC amines; BEETLES; NEUROTRANSMITTERS
- Publication
International Journal of Molecular Sciences, 2018, Vol 19, Issue 3, p846
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms19030846