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- Title
Angiotensin-Converting Enzymes Play a Dominant Role in Fertility.
- Authors
Pei-Pei Pan; Qi-Tao Zhan; Fang Le; Ying-Ming Zheng; Fan Jin
- Abstract
According to the World Health Organization, infertility, associated with metabolic syndrome, has become a global issue with a 10%-20% incidence worldwide. An accumulating body of evidence has shown that the renin-angiotensin system is involved in the fertility problems observed in some populations. Moreover, alterations in the expression of angiotensin-converting enzyme-1, angiotensin-converting enzyme-2, and angiotensin-converting enzyme-3 might be one of the most important mechanisms underlying both female and male infertility. However, as a pseudogene in humans, further studies are needed to explore whether the abnormal angiotensin-converting enzyme-3 gene could result in the problems of human reproduction. In this review, the relationship between angiotensin-converting enzymes and fertile ability is summarized, and a new procedure for the treatment of infertility is discussed.
- Subjects
ANGIOTENSIN converting enzyme; WORLD Health Organization; METABOLIC syndrome; INFERTILITY; RENIN-angiotensin system; HUMAN reproduction
- Publication
International Journal of Molecular Sciences, 2013, Vol 14, Issue 10, p21071
- ISSN
1661-6596
- Publication type
Article
- DOI
10.3390/ijms141021071