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- Title
Copper-Catalyzed Tandem CC/CO Bond-Forming Reactions of ortho-Halo-β-chlorostyrenes with Ketones: Synthesis of 4-Trifluoromethylbenzoxepines.
- Authors
Sun, Lei ‐ Lei; Hu, Bo ‐ Lun; Tang, Ri ‐ Yuan; Deng, Chen ‐ Liang; Zhang, Xing ‐ Guo
- Abstract
A copper-catalyzed cyclization reaction of trifluoromethyl-containing ortho-halo-β-chlorostyrenes with ketones has been developed. Using a combination of copper(I) bromide, 2,2,6,6-tetramethylheptane-3,5-dione and sodium tert-butoxide, a variety of 4-trifluoromethylbenzoxepines was prepared in moderate to good yields by the tandem α-alkenylation of ketones with subsequent O-arylation.
- Publication
Advanced Synthesis & Catalysis, 2013, Vol 355, Issue 2/3, p377
- ISSN
1615-4150
- Publication type
Article
- DOI
10.1002/adsc.201200784