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- Title
A more accurate profile of Achyrocline satureioides hypocholesterolemic activity.
- Authors
Espiña, Débora Corrêa; Carvalho, Fabiano Barbosa; Zanini, Daniela; Schlemmer, Josiane Bizzi; Coracini, Juliane Dors; Rubin, Maribel Antonello; Morsch, Vera Maria; Schetinger, Maria Rosa Chitolina; Leal, Daniela Bitencourt Rosa; Baiotto, Cléia Rosani; Jaques, Jeandre Augusto dos Santos
- Abstract
The aim of this study was to investigate the effect of the aqueous extract (AE) of Achyrocline satureioides on serum lipid profile, liver oxidative profile and Na+,K+-ATPase activity of rats submitted to a hyperlipidic diet. The animals were divided into four groups: control (C), AE 10% (A10), hyperlipidic (H) and hyperlipidic/AE 10% (HA10). In serum, we measured the levels of total cholesterol (TC), high-density lipoprotein, very-low-density lipoprotein, low-density lipoprotein (LDL) and triglyceride (TG). In liver homogenates, we measured the thiobarbituric acid reactive substances, the carbonyl proteins, the non-protein thiols (NPSHs) and the activity of superoxide dismutase, catalase (CAT) and Na+,K+-ATPase. We observed a significant increase in the TC and LDL levels in the H group. A. satureioides prevented these effects, decreased the TG levels in the HA10 group and increased the NPSH levels in the A10 and HA10 groups. The H group showed an increase in the carbonyl protein level and a decrease in CAT and Na+,K+-ATPase activities. With the use of this model, results show that increased levels of lipids are related to a redox imbalance in the liver, which is also related to the inhibition of Na+,K+-ATPase activity, and that chronic administration of the AE of A. satureioides is capable of changing this profile. Copyright © 2012 John Wiley & Sons, Ltd.
- Publication
Cell Biochemistry & Function, 2012, Vol 30, Issue 4, p347
- ISSN
0263-6484
- Publication type
Article
- DOI
10.1002/cbf.2812