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- Title
Synthesis and Hybridization Properties of an Oligonucleotide Consisting of 1′,4′-Anhydro-2′,5′-dideoxy-2′-(thymin-1-yl)- D-altritol.
- Authors
Guan, Zhu; Tian, Xiao-Bin; Zhang, Liang-Ren; Min, Ji-Mei; Zhang, Li-He
- Abstract
The novel oligonucleotide analogue 7, consisting of 1′,4′-anhydro-2′,5′-dideoxy-2′-(thymin-1-yl)- D-altritol ( 4), residues was synthesized by the phosphoramidite approach on an automated DNA synthesizer. The phosphoramidite building block 6 was obtained by phosphitylation of the corresponding isonucleoside 5. Oligoisonucleotide 7 contains an extended phosphodiester linkage with a higher flexibility. Oligoisonucleotide 7 was studied with respect to hybridization properties, enzymatic stability, and CD spectra. It exhibits a high stability towards snake-venom phosphodiesterase and an acceptable hybridization to complementary single-stranded DNA and RNA.
- Publication
Helvetica Chimica Acta, 2002, Vol 85, Issue 5, p1479
- ISSN
0018-019X
- Publication type
Article
- DOI
10.1002/1522-2675(200205)85:5<1479::AID-HLCA1479>3.0.CO;2-P