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- Title
Germline mutation and protein expression analysis of mismatch repair genes MSH6 and PMS2 in Malaysian Lynch syndrome patients.
- Authors
Zahary, Mohd; Kaur, Gurjeet; Hassan, Muhammad; Sidek, Ahmad; Singh, Harjinder; Yeh, Lee; Ankathil, Ravindran
- Abstract
The article discusses a study which examines the spectrum of germline mutation and protein expression of DNA mismatch repair (MMR) genes MSH6 and PMS2 in Malaysian patients with Lynch syndrome. Results revealed that five Lynch syndrome patients were found to harbor germline mutations with a frequency of 8.0 % for PMS2 and 10.0 % for MSH6. It indicated that the mutation frequency of both genes was higher in Malaysian Lynch syndrome patients compared to mutation frequencies in other populations.
- Subjects
GERM cells -- Ultrastructure; GENETIC mutation; DNA repair; CANCER patients; LYNCH syndrome II; GENETIC genealogy; PMS genes
- Publication
International Journal of Colorectal Disease, 2014, Vol 29, Issue 2, p261
- ISSN
0179-1958
- Publication type
Letter
- DOI
10.1007/s00384-013-1770-1