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- Title
Calvarial remodelling for sagittal synostosis: does fibrin glue (Tisseel™) reduce post-operative blood transfusion requirements?
- Authors
White, Nicholas; Carver, Edmund D.; Rodrigues, Desiderio; Dover, Stephen; Magdum, Shailendra; Nishikawa, Hiroshi; Solanki, Guirish
- Abstract
Calvarial remodelling for sagittal synostosis is extensive surgery and is associated with potential risks; the most significant of these is blood loss. We studied 16 patients undergoing calvarial remodelling by the same surgical team over a 12-month period to determine whether scalp closure with fibrin glue (Tisseel™) could decrease post-operative bleeding and the need for blood transfusion. In the last 5 months of the period studied, fibrin glue (Tisseel™) was used and six out of the 16 patients had their wound closure assisted by this means. Data was prospectively collected on age at surgery, the estimated peri-operative blood loss, the volume of blood transfused intra-operatively, the volume drained in the first 8 h post-operatively, the total post-operative drainage and the volume of any post-operative blood transfusion required. The two groups were comparable with a similar mean age at surgery, estimated peri-operative blood loss and intra-operative blood transfusion requirements. The volume drained in the first 8 h post-operatively was 172 ml in the treated group compared to 246 ml in the untreated group ( p < 0.02) and the total post-operative drain volume was 301 ml compared to 441 ml ( p < 0.01). None out of the six patients treated with fibrin glue required post-operative transfusion compared to two out of ten in the untreated group. The use of fibrin glue has enabled us to reduce post-operative bleeding and the need for post-operative blood transfusion.
- Subjects
BLOOD transfusion; SURGERY; HEMORRHAGE; CRANIOSYNOSTOSES; SKULL diseases
- Publication
Child's Nervous System, 2009, Vol 25, Issue 7, p867
- ISSN
0256-7040
- Publication type
Article
- DOI
10.1007/s00381-009-0851-5