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- Title
EWSR1-BEND2 fusion defines an epigenetically distinct subtype of astroblastoma.
- Authors
Lucas, Calixto-Hope G.; Gupta, Rohit; Wu, Jasper; Shah, Kathan; Ravindranathan, Ajay; Barreto, Jairo; Gener, Melissa; Ginn, Kevin F.; Prall, Owen W. J.; Xu, Huiling; Kee, Damien; Ko, Hyun S.; Yaqoob, Nausheen; Zia, Nida; Florez, Adriana; Cha, Soonmee; Perry, Arie; Clarke, Jennifer L.; Chang, Susan M.; Berger, Mitchel S.
- Abstract
Here we show that gliomas with I EWSR1-BEND2 i fusion exhibit astroblastoma-like histologic features and resolve into a single epigenetic subgroup most similar to the methylation class "HGNET, MN1" that encompasses the new tumor type astroblastoma, I MN1 i -altered. The biologic relationship of these gliomas with I EWSR1-BEND2 i fusion compared to the newly defined tumor type "astroblastoma, I MN1 i -altered" is currently unresolved. TSNE clustering of the DNA methylation data alongside a reference cohort of CNS tumors revealed that the I EWSR1-BEND2 i fused gliomas resolved into a single epigenetic group that was divergent from all established reference methylation classes of CNS tumors, but was in close proximity to "High-grade neuroepithelial tumor, I MN1 i -altered" (Fig.
- Subjects
BRAIN stem; FRONTAL lobe; CENTRAL nervous system tumors
- Publication
Acta Neuropathologica, 2022, Vol 143, Issue 1, p109
- ISSN
0001-6322
- Publication type
Article
- DOI
10.1007/s00401-021-02388-y