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- Title
Increased Platelet-Monocyte Interaction in Stable COPD in the Absence of Platelet Hyper-Reactivity.
- Authors
Aleva, Floor E.; Temba, Godfrey; de Mast, Quirijn; Simons, Sami O.; de Groot, Philip G.; Heijdra, Yvonne F.; van der Ven, André J.A.M.
- Abstract
Background: Chronic obstructive pulmonary disease (COPD) is well known for its cardiovascular co-morbidities. Increased platelet-monocyte interaction is found in COPD and may reflect altered platelet function and a potential role for antiplatelet therapy. Objectives: The objectives were to investigate platelet-monocyte interaction, platelet activation and reactivity and plasmatic coagulation in stable COPD. Methods: Platelet-monocyte interaction and platelet activation were determined by flow cytometry in 30 stable COPD patients and 25 controls. Platelet activation was measured by binding of fibrinogen to the activated fibrinogen receptor and platelet P-selectin expression at baseline and after platelet stimulation with platelet agonists. Plasmatic coagulation was measured by D-dimer and thrombin generation. Results: Platelet-monocyte interaction was increased in stable COPD (median fluorescence intensity of platelet CD61 was 19.8 [IQR 14.0-33.2] vs. 10.0 [IQR 8.7-16.7], p = 0.002). In con trast, platelet activation and reactivity, reflected by fibrinogen binding and P-selectin expression, were the same in both groups. Plasma P-selectin and interleukin-6 were increased in COPD (p = 0.01 and p = 0.02, respectively), whereas soluble fibrinogen, D-dimer and thrombin generation were similar. Conclusions: Increased platelet-monocyte interaction was found in the absence of platelet hyper-reactivity and activation of plasmatic coagulation in stable COPD. Future clinical evaluation of the effects of different antiplatelet drugs in COPD is warranted, as anti-platelet therapy may interfere with platelet-monocyte interaction.
- Subjects
BLOOD platelets; OBSTRUCTIVE lung diseases; RESEARCH methodology; MONOCYTES
- Publication
Respiration, 2018, Vol 95, Issue 1, p35
- ISSN
0025-7931
- Publication type
Article
- DOI
10.1159/000480457