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Microphysiological systems in early stage drug development: Perspectives on current applications and future impact.
Published in:
Journal of Toxicological Sciences, 2021, v. 46, n. 3, p. 99, doi. 10.2131/jts.46.99
By:
- Kopec, Anna K.;
- Ryuji Yokokawa;
- Khan, Nasir;
- Ikuo Horii;
- Finley, James E.;
- Bono, Christine P.;
- Donovan, Carol;
- Roy, Jessica;
- Harney, Julie;
- Burdick, Andrew D.;
- Jessen, Bart;
- Shuyan Lu;
- Collinge, Mark;
- Sadeghian, Ramin Banan;
- Derzi, Mazin;
- Tomlinson, Lindsay;
- Burkhardt, John E.
Publication type:
Article
Dietary Docosahexaenoic Acid Prevents Silica-Induced Development of Pulmonary Ectopic Germinal Centers and Glomerulonephritis in the Lupus-Prone NZBWF1 Mouse.
Published in:
Frontiers in Immunology, 2018, p. 1, doi. 10.3389/fimmu.2018.02002
By:
- Bates, Melissa A.;
- Akbari, Peyman;
- Gilley, Kristen N.;
- Wagner, James G.;
- Ning Li;
- Kopec, Anna K.;
- Wierenga, Kathryn A.;
- Jackson-Humbles, Daven;
- Brandenberger, Christina;
- Holian, Andrij;
- Benninghoff, Abby D.;
- Harkema, Jack R.;
- Pestka, James J.
Publication type:
Article
Loss of Hif-2α Rescues the Hif-1α Deletion Phenotype of Neonatal Respiratory Distress In Mice.
Published in:
PLoS ONE, 2015, v. 10, n. 10, p. 1, doi. 10.1371/journal.pone.0139270
By:
- Saini, Yogesh;
- Proper, Steven P.;
- Dornbos, Peter;
- Greenwood, Krista K.;
- Kopec, Anna K.;
- Lynn, Scott G.;
- Grier, Elizabeth;
- Burgoon, Lyle D.;
- Zacharewski, Timothy R.;
- Thomas, Russell S.;
- Harkema, Jack R.;
- LaPres, John J.
Publication type:
Article
Requirement of focal adhesion kinase in branching tubulogenesis.
Published in:
Journal of Biomedical Science, 2009, v. 16, p. 1, doi. 10.1186/1423-0127-16-5
By:
- Wei-Chun Wei;
- Kopec, Anna K.;
- Ming-Jer Tang
Publication type:
Article
Zucker Lean Rats With Hepatic Steatosis Recapitulate Asymptomatic Metabolic Syndrome and Exhibit Greater Sensitivity to Drug-Induced Liver Injury Compared With Standard Nonclinical Sprague-Dawley Rat Model.
Published in:
Toxicologic Pathology, 2020, v. 48, n. 8, p. 994, doi. 10.1177/0192623320968716
By:
- LaBranche, Timothy P.;
- Kopec, Anna K.;
- Mantena, Srinivasa R.;
- Hollingshead, Brett D.;
- Harrington, Andrew W.;
- Stewart, Zachary S.;
- Zhan, Yutian;
- Hayes, Kyle D.;
- Whiteley, Laurence O.;
- Burdick, Andrew D.;
- Davis II, John W.
Publication type:
Article
Thrombin promotes diet-induced obesity through fibrin-driven inflammation.
Published in:
2017
By:
- Kopec, Anna K.;
- Abrahams, Sara R.;
- Thornton, Sherry;
- Palumbo, Joseph S.;
- Mullins, Eric S.;
- Divanovic, Senad;
- Weiler, Hartmut;
- Owens III, A. Phillip;
- Mackman, Nigel;
- Goss, Ashley;
- van Ryn, Joanne;
- Luyendyk, James P.;
- Flick, Matthew J.;
- Owens, A Phillip 3rd
Publication type:
journal article
Dose-dependent effects of alpha-naphthylisothiocyanate disconnect biliary fibrosis from hepatocellular necrosis.
Published in:
Journal of Biochemical & Molecular Toxicology, 2017, v. 31, n. 1, p. 1, doi. 10.1002/jbt.21834
By:
- Joshi, Nikita;
- Ray, Jessica L.;
- Kopec, Anna K.;
- Luyendyk, James P.
Publication type:
Article
Comparative Toxicogenomic Examination of the Hepatic Effects of PCB126 and TCDD in Immature, Ovariectomized C57BL/6 Mice.
Published in:
Toxicological Sciences, 2008, v. 102, n. 1, p. 61, doi. 10.1093/toxsci/kfm289
By:
- Kopec, Anna K.;
- Boverhof, Darrell R.;
- Burgoon, Lyle D.;
- Ibrahim-Aibo, Daher;
- Harkema, Jack R.;
- Tashiro, Colleen;
- Chittim, Brock;
- Zacharewski, Timothy R.
Publication type:
Article
Perspectives on the Evaluation and Adoption of Complex In Vitro Models in Drug Development: Workshop with the FDA and the Pharmaceutical Industry (IQ MPS Affiliate).
Published in:
Altex, 2022, v. 39, n. 2, p. 297, doi. 10.14573/altex.2112203
By:
- Baran, Szczepan W.;
- Brown, Paul C.;
- Baudy, Andreas R.;
- Fitzpatrick, Suzanne C.;
- Frantz, Christopher;
- Fullerton, Aaron;
- Gan, Jinping;
- Hardwick, Rhiannon N.;
- Hillgren, Kathleen M.;
- Kopec, Anna K.;
- Liras, Jennifer L.;
- Mendrick, Donna L.;
- Nagao, Ryan;
- Proctor, William R.;
- Ramsden, Diane;
- Ribeiro, Alexandre J. S.;
- Stresser, David;
- Sung, Kyung E.;
- Sura, Radhakrishna;
- Tetsuka, Kazuhiro
Publication type:
Article
Considerations from an International Regulatory and Pharmaceutical Industry (IQ MPS Affiliate) Workshop on the Standardization of Complex In Vitro Models in Drug Development.
Published in:
Advanced Biology, 2024, v. 8, n. 8, p. 1, doi. 10.1002/adbi.202300131
By:
- Tomlinson, Lindsay;
- Ramsden, Diane;
- Leite, Sofia Batista;
- Beken, Sonja;
- Bonzo, Jessica A.;
- Brown, Paul;
- Candarlioglu, Pelin L.;
- Chan, Tom S.;
- Chen, Eugene;
- Choi, Colin K.;
- David, Rhiannon;
- Delrue, Nathalie;
- Devine, Patrick J.;
- Ford, Kevin;
- Garcia, Martha Iveth;
- Gosset, James R.;
- Hewitt, Philip;
- Homan, Kimberly;
- Irrechukwu, Onyi;
- Kopec, Anna K.
Publication type:
Article
Caspase Inhibition Reduces Hepatic Tissue Factor-Driven Coagulation In Vitro and In Vivo.
Published in:
Toxicological Sciences, 2018, v. 162, n. 2, p. 396, doi. 10.1093/toxsci/kfx268
By:
- Kopec, Anna K;
- Spada, Alfred P;
- Contreras, Patricia C;
- Mackman, Nigel;
- Luyendyk, James P
Publication type:
Article
Trichloroethylene Exposure Reduces Liver Injury in a Mouse Model of Primary Biliary Cholangitis.
Published in:
Toxicological Sciences, 2017, v. 156, n. 2, p. 428, doi. 10.1093/toxsci/kfw264
By:
- Ray, Jessica L.;
- Kopec, Anna K.;
- Joshi, Nikita;
- Cline-Fedewa, Holly;
- Lash, Lawrence H.;
- Williams, Kurt J.;
- Leung, Patrick S.;
- Gershwin, M. Eric;
- Luyendyk, James P.
Publication type:
Article
Coagulation-Driven Hepatic Fibrosis Requires Protease Activated Receptor-1 (PAR-1) in a Mouse Model of TCDD-Elicited Steatohepatitis.
Published in:
Toxicological Sciences, 2016, v. 154, n. 2, p. 381, doi. 10.1093/toxsci/kfw175
By:
- Nault, Rance;
- Fader, Kelly A.;
- Kopec, Anna K.;
- Harkema, Jack R.;
- Zacharewski, Timothy R.;
- Luyendyk, James P.
Publication type:
Article
Toxicogenomic Analysis Reveals Profibrogenic Effects of Trichloroethylene in Autoimmune-Mediated Cholangitis in Mice.
Published in:
Toxicological Sciences, 2014, v. 141, n. 2, p. 515, doi. 10.1093/toxsci/kfu148
By:
- Kopec, Anna K.;
- Sullivan, Bradley P.;
- Kassel, Karen M.;
- Joshi, Nikita;
- Luyendyk, James P.
Publication type:
Article
Fas-Induced Apoptosis Increases Hepatocyte Tissue Factor Procoagulant Activity In Vitro and In Vivo.
Published in:
Toxicological Sciences, 2014, v. 141, n. 2, p. 453, doi. 10.1093/toxsci/kfu139
By:
- Lopez, Michelle;
- Kopec, Anna K.;
- Joshi, Nikita;
- Geddings, Julia E.;
- Cline, Holly;
- Towery, Keara L.;
- Rockwell, Cheryl E.;
- Mackman, Nigel;
- Luyendyk, James P.
Publication type:
Article
Toxicogenomic Evaluation of Long-term Hepatic Effects of TCDD in Immature, Ovariectomized C57BL/6 Mice.
Published in:
Toxicological Sciences, 2013, v. 135, n. 2, p. 465, doi. 10.1093/toxsci/kft156
By:
- Kopec, Anna K.;
- Boverhof, Darrell R.;
- Nault, Rance;
- Harkema, Jack R.;
- Tashiro, Colleen;
- Potter, Dave;
- Sharratt, Bonnie;
- Chittim, Brock;
- Zacharewski, Timothy R.
Publication type:
Article
Investigation of the Mode of Action Underlying the Tumorigenic Response Induced in B6C3F1 Mice Exposed Orally to Hexavalent Chromium.
Published in:
Toxicological Sciences, 2011, v. 123, n. 1, p. 58, doi. 10.1093/toxsci/kfr164
By:
- Thompson, Chad M.;
- Proctor, Deborah M.;
- Haws, Laurie C.;
- Hébert, Charles D.;
- Grimes, Sheila D.;
- Shertzer, Howard G.;
- Kopec, Anna K.;
- Hixon, J.Gregory;
- Zacharewski, Timothy R.;
- Harris, Mark A.
Publication type:
Article
Automated Dose-Response Analysis and Comparative Toxicogenomic Evaluation of the Hepatic Effects Elicited by TCDD, TCDF, and PCB126 in C57BL/6 Mice.
Published in:
Toxicological Sciences, 2010, v. 118, n. 1, p. 286, doi. 10.1093/toxsci/kfq236
By:
- Kopec, Anna K.;
- Burgoon, Lyle D.;
- Ibrahim-Aibo, Daher;
- Burg, Ashley R.;
- Lee, Andrea W.;
- Tashiro, Colleen;
- Potter, Dave;
- Sharratt, Bonnie;
- Harkema, Jack R.;
- Rowlands, J. Craig;
- Budinsky, Robert A.;
- Zacharewski, Timothy R.
Publication type:
Article

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