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- Title
Cognitive Enhancement of Nobiletin Derived from Citrus Peels in Healthy and Pathological Aging.
- Authors
Maki Kamada; Yasushi Ohizum
- Abstract
As the globally aging population expands, the cognitive decline in aging or neurodegenerative disorders will begets not only individual but social and financial burdens. Using natural products with neuroprotective properties, such as nobiletin identified from citrus peels, would be a highly useful camplemeotaiy approach for inexpensive sustainable treatment of these disturbances. Here, we introduce the effective roles of nobiletin in cognitive improvement under the healthy and pathological conditions. Specifically, nobiletin elicited the restoration from pathological characteristics of Alzheimer's disease, ischemia-induced dementia or the age-related cognitive decline. Besides, intraperitoneal administration of nobiletin in Perkinson's disease model mice recuperated motor and cognitive impairment Fascinatingly, in Hernial mice hippocarnpal slices, nobiletin induced long-term potentiation between Schafler collaterals and CA1 pyramidal cells and facilitated GluR1 phosphorylation in hippocarnpal CA1 area. To date, despite physiologically and pathologically significant data cm these potential neuroprotective effects, clinical studies are still very limited. Nevertheless, adequate intake of nobiletin could confer safety and sustainably health benefits.
- Subjects
ALZHEIMER'S disease; AGE factors in cognition disorders; COGNITION disorders; CITRUS; LONG-term potentiation; PYRAMIDAL neurons; AGE factors in Alzheimer's disease; NEUROFIBRILLARY tangles
- Publication
Pharmacometrics / Ōyō Yakuri (0300-8533), 2019, Vol 97, Issue 3/4, p41
- ISSN
0300-8533
- Publication type
Article