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- Title
Comparison of clinical features of acute hepatitis caused by hepatitis E virus (HEV) genotypes 3 and 4 in Sapporo, Japan
- Authors
Ohnishi, Sachiyo; Kang, Jong-Hon; Maekubo, Hiroshi; Arakawa, Tomohiro; Karino, Yoshiyasu; Toyota, Joji; Takahashi, Kazuaki; Mishiro, Shunji
- Abstract
Abstract: In Japan, indigenous acute hepatitis E is not a rare disease, and is mainly caused by hepatitis E virus (HEV) genotypes 3 and 4. Whether there is a difference in clinical features between the two genotypes remains unclear. This study compares the clinical features of patients infected with the two. From January, 1994, to December, 2003, 9 infected with HEV genotype 3 and 27 patients with genotype 4 were enrolled. Patients with genotype 4 had significantly higher peak alanine aminotransferase levels (median 3430IU/L, interquartile range 1747–4763 versus 1052IU/L, 845–2707; p =0.01). The lowest prothrombin time was lower in the genotype 4 group (61%, 42–77 versus 84%, 70–96; p =0.05). In our series, patients with genotype 4 had longer median duration of hospital stay (26.5 days, 18–31 versus 18 days, 12–23.5; p =0.06). The patients with genotype 4 infection tended to have more severe clinical manifestations than those with genotype 3 infection.
- Subjects
HEPATITIS; LIVER diseases; VIRAL hepatitis; AMINOTRANSFERASES; MEDICAL research
- Publication
Hepatology Research, 2006, Vol 36, Issue 4, p301
- ISSN
1386-6346
- Publication type
Article
- DOI
10.1016/j.hepres.2006.08.002