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- Title
Family History of Cancer and Cancer Risks in Women with BRCA1 or BRCA2 Mutations.
- Authors
Metcalfe, Kelly; Lubinski, Jan; Lynch, Henry T.; Ghadirian, Parviz; Foulkes, William D.; Kim-Sing, Charmaine; Neuhausen, Susan; Tung, Nadine; Rosen, Barry; Gronwald, Jacek; Ainsworth, Peter; Sweet, Kevin; Eisen, Andrea; Ping Sun; Narod, Steven A.
- Abstract
Women who carry a deleterious mutation in BRCA1 or BRCA2 have high lifetime risks of breast and ovarian cancers. However, the influence of a family history of these cancers on these risks in women with BRCA mutations is unclear. We calculated cancer incidence rates for a multinational cohort comprising 3011 women with BRCA1 or BRCA2 mutations who were followed up for a mean of 3.9 years, during which time 243 incident breast or ovarian cancers were recorded. The 10-year cumulative risks of breast cancer were 18.1% (95% confidence interval [CI] = 13.3% to 22.8%) for women with a BRCA1 mutation and 15.2% (95% CI = 9.1% to 21.2%) for women with a BRCA2 mutation. Among women with a BRCA1 mutation, the risk of breast cancer increased by 1.2-fold for each first-degree relative with breast cancer before age 50 years (hazard ratio [HR] = 1.21; 95% confidence interval [CI] = 0.94 to 1.57) and the risk of ovarian cancer increased by 1.6 fold for each first- or second-degree relative with ovarian cancer (HR = 1.61; 95% CI = 1.21 to 2.14). Among women with a BRCA2 mutation, the risk of breast cancer increased by 1.7-fold for each first-degree relative younger than 50 years with breast cancer (HR = 1.67; 95% CI = 1.04 to 2.07)
- Subjects
CANCER in women; BREAST cancer research; OVARIAN cancer; FAMILY history (Medicine); CANCER genetics; CANCER risk factors
- Publication
JNCI: Journal of the National Cancer Institute, 2010, Vol 102, Issue 24, p1874
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djq443