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- Title
Effect of Multikinase Inhibitors on Caspase-Independent Cell Death and DNA Damage in HER2-Overexpressing Breast Cancer Cells.
- Authors
Seoane, Samuel; Montero, Juan Carlos; Ocaña, Alberto; Pandiella, Atanasio
- Abstract
Background: The receptor tyrosine kinase, HER2, is overexpressed in approximately 25% of patients with breast cancer and is implicated in the aggressiveness of cancer. Targeting of HER2 signaling with trastuzumab, a monoclonal antibody that inhibits HER2 activity, has demonstrated clinical benefits.
- Subjects
PROTEIN-tyrosine kinases; CELL death; DNA damage; BREAST cancer; CANCER cells
- Publication
JNCI: Journal of the National Cancer Institute, 2010, Vol 102, Issue 18, p1432
- ISSN
0027-8874
- Publication type
Article
- DOI
10.1093/jnci/djq315